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Institute of Chemistry and Biochemistry

The Institute of Chemistry and Biochemistry is responsible for the Bachelor‘s and Master‘s programmes in Chemistry and Chemistry for Education. The research covers biochemistry and structural biology, environmental and analytical chemistry, computational chemistry, and interdisciplinary fields such as biophysical chemistry.


Homepage: http://uch.prf.jcu.cz/
Head of the Department: Assoc.Prof. Šárka Klementová  
E-mail: sklement@jcu.cz

Research and education activities 

Biochemistry

Glycobiology, mainly focused on blood-feeding arthropods. Protein-saccharide interactions in transmission and infectivity of tick-borne pathogens, identification of glycans and glycoproteins of ticks 

Structural chemistry and protein crystallography

X-ray crystallography is the major technique to get the structure of biological macromolecules at atomic resolution. These protein structures are central to understanding the detailed mechanisms of biological processes and to discovering novel therapeutics using a structure-based approach. Structural studies of membrane and soluble biological macromolecular complexes using methods of X-ray diffraction are the main aim of our research.

Light and Photosynthesis - an ultimate source of energy

The structure of photosynthetic light antennae and the function of light harvesting processes are studied to better understand these principal energy conversion processes and as a tool for development of artificial light harvesting systems.

Analytical chemistry

The occurrence of the biologically active compounds and pollutants in the air, water, and plants, their isolation, concentration, and determination with modern instrumental techniques.

Environmental photochemistry

The photochemical degradation of resistant pollutants (herbicides, hormones, cosmetic preservatives) is investigated in systems relevant to fresh water bodies, toxicity of photoproducts is tested.

Computational chemistry

We deal mainly with the interactions of inorganic surfaces with organic molecules and biomolecules in order to find the ideal conditions for trapping toxic organic compounds from water on mineral surfaces, or to ensure the suitable procedure for the preparation of biosensors.

Example of results

Publications:

KLEMENTOVÁ Š., KAHOUN D., DOUBKOVÁ L., FREJLACHOVÁ K., DUŠÁKOVÁ M., ZLÁMAL M. (2017): Catalytic photodegradation of pharmaceuticals – homogeneous and hetrogeneous photocatalysis. Photobiol. Sci. 16, 67-71.

KAHOUN D., ŘEZKOVÁ S., KRÁLOVSKÝ J. (2017): Effect of heat treatment and storage conditions on mead compostion. Food Chemistry 219, 357-363.

SVIRIDOVA E., REZACOVA P., BONDAR A., VEVERKA V., NOVAK P., SCHENK G., SVERGUM D.I., KUTA SMATANOVA I. & BUMBA L., (2017): Structural basis of the interaction between the putative adhesion-involved and iron-regulated FrpD and FrpC proteins of Neisseria meningitides. Sci. Rep. 7, pages 14, 40408. doi: 10.1038/srep40408.

BÍNA D., GARDIAN Z., VÁCHA F., LITVÍN R. (2016): Native FMO-reaction center supercomplex in green sulfur bacteria: an electron microscopy study. Photosynth. Res. 128, 93-102

BÍNA D., HERBSTOVÁ M., GARDIAN Z., VÁCHA F., LITVÍN R. (2016): Novel structural aspect of diatom thylakoid membrane: lateral segregation of photosystem I under red-enhanced illumination. Scientific Reports 6,  Article Number: 25583

KRISHNA S., MASLANI A., IZDEBSKI T., HORÁKOVÁ M., KLEMENTOVÁ Š., ŠPATENKA P. (2016): Degradation of Verapamil hydrochloride in water by gliding arc discharge. Chemosphere 152, 47-54.

SHALIUTINA -KOLEŠOVÁ A., KOTAS P., ŠTĚRBA J., RODINA M., DZYUBA B., COSSON J., LINHART O. (2016): Protein profile of seminal plasma and functionality of spermatozoa during the reproductive season in the common carp (/Cyprinuscarpio/) and rainbow trout (/Oncorhynchus mykiss/). Mol Reprod Dev. 83(11):968-982.

DONALD C.L., BRENNAN B., CUMBERWORTH S.L., REZELJ V.V., CLARK J.J., CORDEIRO M.T., FREITAS DE OLIVEIRA FRANCA R., PENA L.J., WILKIE G.S., DA SILVA FILIPE A., DAVIS C., HUGHES J., VARJAK M., SELINGER M., ZUVANOV L., OWSIANKA A.M., PATEL A.H., MCLAUCHLAN J., LINDENBACH B.D., FALL G., SALL A.A., BIEK R., REHWINKEL J., SCHNETTLER E., KOHL A. (2016): Full Genome Sequence and sfRNA Interferon Antagonist Activity of Zika Virus from Recife, Brazil. PLoS Negl Trop Dis. 2016 10(10):e0005048.

BREZOVSKY J., BABKOVA P., DEGTJARIK O., FORTOVA A., GORA A., IERMAK I., REZACOVA P., DVORAK P., KUTA SMATANOVA I., PROKOP Z., CHALOUPKOVA R. & DAMBORSKY J. (2016). Engineering a de novo transport tunnel. ACS Catalysis 6, 7597-7610. DOI: 10.1021/acscatal.6b02081