Mechanismy: Mechanisms and dynamics of macromolecular complexes: from single molecules to cells

01.01.2017

Tůma Roman, Department of Chemistry
01 Jan 2017 – 31 Oct 2023
MŠMT OPVVV 02-15-003


Mechanismy (ID CZ.02.1.01/0.0/0.0/15_003/0000441)
Název CZ: Mechanismy a dynamika makromolekulárních komplexů: Od jednotlivých molekul po buňky
Název EN: Mechanisms and dynamics of macromolecular complexes: from single molecules to cells
PI: Tůma Roman, Department of Chemistry
Implementation: 01 Jul 2021 – 30 Jun 2023
Budget: 207 409 734 CZK (SCI), 176 298 273,90 CZK (MŠMT subsidy) + 10 370 486,70 CZK (5% SCI co-funding)
Provider: MŠMT 
Call: OPVVV 02-15-003

http://makrokomplex.cz/

Abstract

The aim of this project is to establish an international research team, headed by a key foreign scientist (KFS) Roman Tůma, which will focus on the molecular mechanisms of large macromolecular assemblies. The project will build interdisciplinary centre that integrates individual approaches to solve common set of aims. This approach will enable us to overcome limitations of the methods, such as spatial and temporal resolution and yield full description of the processes involved in the function of the assemblies at the molecular level.

Objectives

Specific aims of the project stem from the current research in the group of KFS and builds on the existing strengths of the recipient institution in biophysics, photosynthesis and time resolved optical techniques. These techniques will be further developed and integrated with structural approaches such as high resolution electron microscopy, X-ray diffraction and native mass spectrometry. The aims are to elucidate mechanisms of assembly and function of large macromolecular complexes such as photosynthetic antennae and RNA viruses, structure and function of long non-coding RNAs in cellular regulation, mechanism of recombination in immune cell precursors and link to certain types of leukaemia, mechanism of chromatin remodelling, and function membrane transport complexes in bacteria and protozoa. The project will strengthen international collaboration and standing of the centre and will lead to new collaborative initiatives with the strategic partners (Johannes Kepler University, Austria, University of Leeds, United Kingdom) and other institutions.

Outputs

  • Number of new researchers in supported subjects (CO 24): 10
  • Number of researchers working in modernized research infrastructures (CO25): 14,6
  • Number of newly built, expanded or modernized research infrastructure and centers of excellence (2 4000): 1
  • Number of participations of supported research teams implemented in international cooperation programme (2 03 12): 2
  • Percentage of scientific publications (selected types of documents) in co-authorship of domestic and foreign researchers (2 02 14): 40