PhD defense of Jan Kotal


Tuesday Dec 15th 2020 at 10 am

Defense ONLINE via MS Teams

Functional analysis of tick salivary serine and cysteine protease inhibitors

Annotation:
The proposed thesis focuses on the characterization of two protease inhibitors
present in tick saliva. More specifically, the thesis presents
immunomodulatory properties, biochemical specificity and structure of a
cysteine protease inhibitor named Iristatin. Another characterized protein,
IRS-8, comes from a serpin family (serine protease inhibitors) and inhibits
blood coagulation and complement system in the host. Furthermore, the thesis
provides a literature overview and discussion of tick salivary molecules in the
context of tick-host-pathogen interaction, vaccination potential and medicine
potential. Two review manuscripts, which are part of this thesis summarize
the effects of tick saliva and protease inhibitors on host immune mechanisms.