Katedra molekulární biologie a genetiky
Department of molecular biology and genetics
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Laboratory of Comparative Cytogenetics and Genomics


People
RNDr. Petr Nguyen, Ph.D. (PI)

RNDr. Martina Dalíková, Ph.D. (post-doctoral researcher)
RNDr. Anna Voleníková (researcher)
M.Sc. Irena (Hladová) Provazníková (Ph.D. student)

B.Sc. Monika Kreklová (M.Sc. student)
B.Sc. Veronika Běhálková (M.Sc. student)
Monika Hrubá (B.Sc. student)
Aneta Pilíková (B.Sc. student)
Karolína Petřvalská (B.Sc. student)

Research
We are interested in the role of genome organization and its changes in evolution. Particularly, we have been investigating:

Karyotype evolution in arthropods.

Sadílek D, Nguyen P, Koç H., Kovařík F, Yagmur E, Štáhlavský F (2015) Molecular cytogenetics of the Androctonus scorpions: Oasis of calm in turbulent karyotype evolution of the diverse family Buthidae. Biological Journal of the Linnean Society 115: 69-76. DOI: 10.1111/bij.12488

Nguyen P, Sahara K, Yoshido A, Marec F (2010) Evolutionary dynamics of rDNA clusters on chromosomes of moths and butterflies (Lepidoptera). Genetica 138: 343–354. DOI: 10.1007/s10709-009-9424-5

Role of chromosome rearrangements in evolution.

Štundlová J, Šmíd J, Nguyen P, Šťáhlavský F (2019) Cryptic diversity and dynamic chromosome evolution in Alpine scorpions (Euscorpiidae: Euscorpius). Molecular Phylogenetics and Evolution 134: 152-163.

Evolutionary origin of the W chromosome in moths and butterflies (Lepidoptera), the largest taxon with female heterogamety (i.e. WZ/ZZ sex chromosome system).

Dalíková M, Zrzavá M, Hladová I, Nguyen P, Šonský I, Flegrová M, Kubíčková S, Voleníková A, Kawahara AY, Peters RS, Marec F (2017) New insights into the evolution of the W chromosome in Lepidoptera. Journal of Heredity 108: 709-719. DOI: 10.1093/jhered/esx063

Evolution of lepidopteran neo-sex chromosomes.

Carabajal Paladino LZ, Provazníková I, Berger M, Bass C, Aratchige NS, López SN, Marec F, Nguyen P (2019) Sex chromosome turnover in moths of the diverse superfamily Gelechioidea. Genome Biology and Evolution 11: 1307–1319. DOI: 10.1093/gbe/evz075

Nguyen P, Carabajal Paladino LZ (2016) On the neo-sex chromosomes of Lepidoptera. In: Pontarotti P (ed.): Evolutionary Biology: Convergent Evolution, Evolution of Complex Traits, Concepts and Methods. Springer, Heidelberg, ISBN: 978-3-319-41324-2, pp. 171-185. DOI: 10.1007/978-3-319-41324-2_11

Nguyen P, Sýkorová M, Šíchová J, Kůta V, Dalíková M, Čapková Frydrychová R, Neven LG, Sahara K, Marec F (2013) Neo-sex chromosomes and adaptive potential in tortricid pests. Proceedings of the National Academy of Sciences of the United States of America 110: 6931-6936. DOI: 10.1073/pnas.1220372110

Genetics and genomics of insect pests.

Wan F, Yin C, Tang R, Chen M, Wu Q, Huang C, Qian W, Rota-Stabelli O, Yang N, Wang S, Wang G, Zhang G, Guo J, Gu L, Chen L, Xing L, Xi Y, Liu F, Lin K, Guo M, Liu W, He K, Tian R, Jacquin-Joly E, Franck P, Siegwart M, Ometto L, Anfora G, Blaxter M, Meslin C, Nguyen P, Dalíková M, Marec F, Olivares J., Maugin S., Shen J., Liu J., Guo J., Luo J., Liu B., Fan W., Feng L., Zhao X., Peng X., Wang K., Liu L, Zhan H, Liu W, Shi G, Jiang C, Jin J, Xian X, Lu S, Ye M, Li M, Yang M, Xiong R, Walters JR, Li F (2019) A chromosome-level genome assembly of Cydia pomonella provides insights into chemical ecology and insecticide resistance. Nature Communications 10: 4237. DOI: 10.1038/s41467-019-12175-9

Meccariello A, Salvemini M, Primo P, Hall B, Koskinioti P, Dalíková M, Gravina A, Gucciardino MA, Forlenza F, Gregoriou ME, Ippolito D, Monti SM, Petrella V, Perrotta MM, Schmeing S, Ruggiero A, Scolari F, Giordano E, Tsoumani KT, Marec F, Windbichler N, Arunkumar KP, Bourtzis K, Mathiopoulos KD, Ragoussis J, Vitagliano L, Tu Z, Papathanos PA, Robinson MD, Saccone G (2019) Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests. Science 365: 1457–1460. DOI: 10.1126/science.aax1318

Sauer AJ, Fritsch E, Undorf-Spahn K, Nguyen P, Marec F, Heckel DG, Jehle JA (2017) Novel resistance to Cydia pomonella granulovirus (CpGV) in codling moth shows autosomal and dominant inheritance and confers cross-resistance to different CpGV genome groups. PLoS ONE 12: e0179157. DOI: 10.1371/journal.pone.0179157