supervisor: RNDr. Jindřich Chmelař, Ph.D.
topic of dissertation thesis: Anti-inflammatory and immunomodulatory activities of Ixodes ricinus salivary proteins
Adéla Chlastáková studied Biomedical Laboratory Techniques and Clinical Biology at the Faculty of Science of the University of South Bohemia in České Budějovice. Since February 2017, she has been a PhD student in Infection Biology. Her research interests centre around the functional characterization of tick salivary serpins and cystatins, with an emphasis on their anti-inflammatory and immunomodulatory activities. Over the course of her studies, she has developed skill in using several immunological and molecular techniques (e.g. flow cytometry, ELISA, and qPCR). When working at her master thesis, she optimized two animal models of inflammation – thioglycolate-induced peritonitis and carrageenan-induced paw oedema – for assessing anti-inflammatory activities of various substances, including tick proteins. In addition to research activities, she is responsible for the care and management of laboratory animals.
Kotál J., Stergiou N., Buša M., Chlastáková A., Beránková Z., Řezáčová P., Langhansová H., Schwarz A., Calvo E., Kopecký J., Mareš M., Schmitt E., Chmelař J., Kotsyfakis M. (2019) The structure and function of Iristatin, a novel immunosuppressive tick salivary cystatin Cellular and Molecular Life Sciences 76: 2003–2013.