Dr. Daniel Ruzek completed his Master’s studies of Clinical Biology and PhD studies of Molecular and Cellular Biology and Genitics at the Faculty of Biological Sciences/Faculty of Science, University of Soth Bohemia. In 2008-2009, he received a postdoctoral training in Virology at the Department of Immunology and Virology, Texas Biomedical Research Institute, San Antonio, USA. He is an Associate Professor in the field of Medical Microbiology (awarded by the Faculty of Military Health Sciences, University of Defence). He is a Head of the Laboratory of Arbovirology, Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, and Head of the Department of Virology, Veterinary Research Institute in Brno. He teaches Medical Virology course at the Faculty of Science USB and Pathogenesis of Viral Diseases at the Masaryk University in Brno. His main research interest include vector-borne viruses, in particular tick-borne encephalitis virus.
More information at: https://www.paru.cas.cz/en/staff/profile/71/
Our research is focused mainly on tick-borne encephalitis and other important arboviral infections. We investigate pathogenesis of tick-borne encephalitis, with special focus on mechanisms involved in virus neuroinvasion and interaction with CNS cells. We are also working on the development and testing of novel antivirals and vaccines. Our laboratory has a BSL-3 facility, allowing us to study highly pathogenic human viruses.
Institute of Parasitology, Biology Centre of the Czech Academy of Sciences
Veterinary Research Institute, Brno
Selected collaborating institutions:
Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences
Hokkaido University, Sapporo, Japan
Central European Institute of Technology
Rega Institute, Leuven, Belgium
Robert Koch-Institut, Berlin, Germany
Institut Pasteur, Paris, France
Institute of Virology, Biomedical Centre of the Slovak Academy of Sciences
Hospital in Ceske Budejovice
Institute of Bioorganic Chemistry and Fundamental Medicine, Russian Academy of Science, Novosibirsk, Russia
Füzik T, Formanová P, Růžek D, Yoshii K, Niedrig M, Plevka P. Structure of tick-borne encephalitis virus and its neutralization by a monoclonal antibody. Nature Communications 2018 Jan 30;9(1):436.
Růžek, D., Yakimenko, V.V., Karan, L.S., Tkachev, S.E. (2010). Omsk haemorrhagic fever. The Lancet 376(9758):2104-13.
Eyer L, Kondo H, Zouharova D, Hirano M, Valdés JJ, Muto M, Kastl T, Kobayashi S, Haviernik J, Igarashi M, Kariwa H, Vaculovicova M, Cerny J, Kizek R, Kröger A, Lienenklaus S, Dejmek M, Nencka R, Palus M, Salat J, De Clercq E, Yoshii K, Ruzek D. Escape of tick-borne flavivirus from 2' -C-methylated nucleoside antivirals is mediated by a single conservative mutation in NS5 that has a dramatic effect on viral fitness. Journal of Virology 2017 Aug 16. pii: JVI.01028-17. doi: 10.1128/JVI.01028-17. (Editors‘ Choice)
Eyer L, Nencka R, Huvarová I, Palus M, Joao Alves M, Gould EA, De Clercq E, Růžek D. Nucleoside Inhibitors of Zika Virus. Journal of Infectious Diseases 2016 Sep 1;214(5):707-11. (Editors’ Choice; Highly cited according to WoS)
Salat J, Mihalca AD, Mihaiu M, Modrý D, Ruzek D. Tick-borne encephalitis in sheep, Romania. Emerging Infectious Diseases, Dec;23(12):2065-2067.
2017-2021 European Regional Fund CZ.02.1.01/0.0/0.0/15_003/0000495 FIT (Pharmacology, Immunotherapy, nanoToxicology) (Scientific Director)
2018-2020 European Joint Programme Cofund under H2020: Metagenomic Array Detection of emerging Viruses in EU (MAD-VIR) (partner)
2020-2022 Czech Science Foundation: GA20-14325S Molecular mechanisms of tick-borne encephalitis pathogenesis (PI)
2019-2022 Ministry of Health of the Czech Republic: NV19-05-00457 Genetic predisposition to different clinical course and severity of tick-borne encephalitis (PI)