Daniel Růžek


Daniel Růžek, Ph.D.

Associate Professor

 (born in 1981)

 

Phone: +420 777 786 218

E-mail: ruzekd@paru.cas.cz

Dr. Daniel Ruzek completed his Master’s studies of Clinical Biology and PhD studies of Molecular and Cellular Biology and Genitics at the Faculty of Biological Sciences/Faculty of Science, University of Soth Bohemia. In 2008-2009, he received a postdoctoral training in Virology at the Department of Immunology and Virology, Texas Biomedical Research Institute, San Antonio, USA. He is an Associate Professor in the field of Medical Microbiology (awarded by the Faculty of Military Health Sciences, University of Defence). He is a Head of the Laboratory of Arbovirology, Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, and Head of the Department of Virology, Veterinary Research Institute in Brno. He teaches Medical Virology course at the Faculty of Science USB and Pathogenesis of Viral Diseases at the Masaryk University in Brno. His main research interest include vector-borne viruses, in particular tick-borne encephalitis virus.

More information at: https://www.paru.cas.cz/en/staff/profile/71/

 

Research focus:

Our research is focused mainly on tick-borne encephalitis and other important arboviral infections. We investigate pathogenesis of tick-borne encephalitis, with special focus on mechanisms involved in virus neuroinvasion and interaction with CNS cells. We are also working on the development and testing of novel antivirals and vaccines. Our laboratory has a BSL-3 facility, allowing us to study highly pathogenic human viruses.

  

Host Institutions:

 Institute of Parasitology, Biology Centre of the Czech Academy of Sciences

Veterinary Research Institute, Brno

  

Selected collaborating institutions:

 Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences

Hokkaido University, Sapporo, Japan

Central European Institute of Technology

Rega Institute, Leuven, Belgium

Robert Koch-Institut, Berlin, Germany

Institut Pasteur, Paris, France

Institute of Virology, Biomedical Centre of the Slovak Academy of Sciences

Hospital in Ceske Budejovice

Institute of Bioorganic Chemistry and Fundamental Medicine, Russian Academy of Science, Novosibirsk, Russia

  

Selected publications:

 Füzik T, Formanová P, Růžek D, Yoshii K, Niedrig M, Plevka P. Structure of tick-borne encephalitis virus and its neutralization by a monoclonal antibody. Nature Communications 2018 Jan 30;9(1):436.

 Růžek, D., Yakimenko, V.V., Karan, L.S., Tkachev, S.E. (2010). Omsk haemorrhagic fever. The Lancet 376(9758):2104-13.

 Eyer L, Kondo H, Zouharova D, Hirano M, Valdés JJ, Muto M, Kastl T, Kobayashi S, Haviernik J, Igarashi M, Kariwa H, Vaculovicova M, Cerny J, Kizek R, Kröger A, Lienenklaus S, Dejmek M, Nencka R, Palus M, Salat J, De Clercq E, Yoshii K, Ruzek D. Escape of tick-borne flavivirus from 2' -C-methylated nucleoside antivirals is mediated by a single conservative mutation in NS5 that has a dramatic effect on viral fitness. Journal of Virology 2017 Aug 16. pii: JVI.01028-17. doi: 10.1128/JVI.01028-17. (Editors‘ Choice)

 Eyer L, Nencka R, Huvarová I, Palus M, Joao Alves M, Gould EA, De Clercq E, Růžek D. Nucleoside Inhibitors of Zika Virus. Journal of Infectious Diseases 2016 Sep 1;214(5):707-11. (Editors’ Choice; Highly cited according to WoS)

 Salat J, Mihalca AD, Mihaiu M, Modrý D, Ruzek D. Tick-borne encephalitis in sheep, Romania. Emerging Infectious Diseases, Dec;23(12):2065-2067.

  

Ongoing grants:

 2017-2021       European Regional Fund CZ.02.1.01/0.0/0.0/15_003/0000495 FIT (Pharmacology, Immunotherapy, nanoToxicology) (Scientific Director)

 2018-2020       European Joint Programme Cofund under H2020: Metagenomic Array Detection of emerging Viruses in EU (MAD-VIR) (partner)

 2020-2022          Czech Science Foundation: GA20-14325S Molecular mechanisms of tick-borne encephalitis pathogenesis (PI)

 2019-2022          Ministry of Health of the Czech Republic: NV19-05-00457 Genetic predisposition to different clinical course and severity of tick-borne encephalitis (PI)