Helena Langhansová


RNDr. Helena Langhansová, Ph.D.

(maiden name Horká)

 

Phone: +420 387 776 291

E-mail: hlanghansova@prf.jcu.cz

building C PřF JU, door 02 039

Helena graduated in Clinical Biology at the Biological Faculty and then got Ph.D. in Molecular and Cellular Biology and Genetics at the Faculty of Science, University of South Bohemia in České Budějovice. In 2009, she spent several months at the Institute for Immunology in Mainz, Germany. Her research within the research group of Jindřich Chmelař is currently dedicated mostly to the expression analysis and functional characterization of tick serpins. She also cooperates with the Laboratory of Plasma Physics at the Department of Physics (USB) in the testing of biocompatibility and antimicrobial properties of various plasma deposits. She is responsible for the organizing of practical courses in Immunology (KME/216 in Czech, KME/723 in English). Since academic year 2018/2019 she guarantees and teaches a new course Experimental Animals in Biomedical Research (KME/086, in Czech).

 

Publications (2015-2019)

Kotál J., Stergiou N., Buša M., Chlastáková A., Beránková Z., Řezáčová P., Langhansová H., Schwarz A., Calvo E., Kopecký J., Mareš M., Schmitt E., Chmelař J., Kotsyfakis M. (2019): The structure and function of Iristatin, a novel immunosuppressive tick salivary cystatin. Cell Moll Life Sci 76: 2003-2013.

Kratochvíl J., Kahoun D., Kylián O., Štěrba J., Kretková T., Kousal J., Hanuš J., Vaclová J., Prysiazhnyi V., Sezemský P., Fojtíková P., Lieskovská J., Langhansová H., Krakovský I., Straňák V. (2019): Nitrogen enriched C:H:N:O thin films for improved antibiotics doping. Appl Surf Sci 494: 301-308.

Širmarová J., Salát J., Palus M., Hönig V., Langhansová H., Holbrook M.R., Růžek D. (2018): Kyasanur Forest Disease virus infection activates human vascular endothelial cells and monocyte-derived dendritic cells. Emerg Microbes Infect 7: 175.

Kratochvíl J., Štěrba J., Lieskovská J., Langhansová H., Kuzminova A., Khalakhan I., Kylián O., Straňák V. (2018): Antibacterial effect of Cu-C:F nanocomposites deposited on PEEK substrates. Mater Lett 230: 96-99.

Frutos E., Karlík M., Jiménez J.A., Langhansová H., Lieskovská J., Polcar T. (2018): Development of new β/α″-Ti-Nb-Zr biocompatible coating with low Young's modulus and high toughness for medical applications. Mater Des 142: 44-55.

Kratochvíl J., Kahoun D., Štěrba J., Langhansová H., Lieskovská J., Fojtíková P., Hanuš J., Kousal J., Kylián O., Straňák V. (2018): Plasma polymerized C:H:N:O thin films for controlled release of antibiotic substances. Plasma Process Polym 15: 1700160.

Lieskovská J., Páleníková J., Langhansová H., Chmelař J., Kopecký J. (2018): Saliva of Ixodes ricinus enhances TBE virus replication in dendritic cells by modulation of pro-survival Akt pathway. Virology 514: 98-105.

Chmelař J., Kotál J., Langhansová H., Kotsyfakis M. (2017): Protease inhibitors in tick saliva: The role of serpins and cystatins in tick-host-pathogen interaction. Front Cell Infect Microbiol 7: 216.

Kotál J., Langhansová H., Lieskovská J., Andersen J.F., Francischetti I.M., Chavakis T., Kopecký J., Pedra J.H., Kotsyfakis M., Chmelař J. (2015): Modulation of host immunity by tick saliva. J Proteomics 128: 58-68.

Klein M., Brühl T.J., Staudt V., Reuter S., Grebe N., Gerlitzki B., Hoffmann M., Bohn T., Ulges A., Stergiou N., de Graaf J., Löwer M., Taube C., Becker M., Hain T., Dietzen S., Stassen M., Huber M., Lohoff M., Campos Chagas A., Andersen J., Kotál J., Langhansová H., Kopecký J., Schild H., Kotsyfakis M., Schmitt E., Bopp T. (2015): Tick salivary sialostatin L represses the initiation of immune responses by targeting IRF4-dependent transcription in murine mast cells. J Immunol 195: 621-631.

Lieskovská J., Páleníková J., Langhansová H., Campos Chagas A., Calvo E., Kotsyfakis M., Kopecký J. (2015): Tick sialostatins L and L2 differentially influence dendritic cell responses to Borrelia spirochetes. Parasit Vectors 8: 275.

Páleníková J., Lieskovská J., Langhansová H., Kotsyfakis M., Chmelař J., Kopecký J. (2015): Ixodes ricinus salivary serpin IRS-2 affects Th17 differentiation via inhibition of the interleukin-6/STAT-3 signaling pathway. Infect Immun 83: 1949-1956.

Langhansová H., Bopp T., Schmitt E., Kopecký J. (2015): Tick saliva increases production of three chemokines including monocyte chemoattractant protein-1, a histamine-releasing cytokine. Parasite Immunol 37: 92-96.