Jan Kopecký


Prof. RNDr. Jan Kopecký, CSc.

(born 1950 in Čáslav)

 

phone: +420 387 776 274

e-mail: jkopec@prf.jcu.cz

building C PřF JU, door 02 038

He studied Microbiology at the Faculty of Science, Charles University in Prague. In 1983 he obtained Ph.D. in Virology at the Military Medical Academy in Hradec Králové. In 2012 he was appointed professor in the field of Parasitology. In 1984-2013 he was the head of the Laboratory of Parasite Immunology at the Institute of Parasitology of AS CR in České Budějovice. In 1991-1996 he completed several stays at the Institute of Virology and Environmental Microbiology in Oxford, England. In his scientific work he focuses on immunology of tick-host-pathogen interactions, on the study of immunomodulatory molecules from tick saliva and their influence on the transmission of tick-borne pathogens (tick-borne encephalitis virus, Borrelia burgdorferi).

At the Faculty of Science, he teaches courses in Immunology, Immunity to Parasites, Cell Line Cultures in Vitro, and specialized courses in Diagnostics of Vector-Transmitted Diseases and Vaccines against Tick-borne pathogens. Until July 2016, he was Head of the Department of Medical Biology.

 

Selected publications:

Kotál J, Langhansová H, Lieskovská J, Andersen JF, Francischetti IM, Chavakis T, Kopecký J, Pedra JH, Kotsyfakis M, Chmelař J. 2015: Modulation of host immunity by tick saliva. J. Proteomics. 128:58-68.

Páleníková J, Lieskovská J, Langhansová H, Kotsyfakis M, Chmelař J, Kopecký J. 2015: Ixodes ricinus salivary serpin IRS-2 affects Th17 differentiation via inhibition of the interleukin-6/STAT-3 signaling pathway. Infect Immun. 83: 1949-1956.

Lieskovská J, Páleníková J, Langhansová H, Campos Chagas A, Calvo E, Kotsyfakis M, Kopecký J. 2015: Tick sialostatins L and L2 differentially influence dendritic cell responses to Borrelia spirochetes. Parasit Vectors.  8: 275.

Klein M, Brühl TJ, Staudt V, Reuter S, Grebe N, Gerlitzki , Hoffmann M, Bohn T, Ulges A, Stergiou N, de Graaf J, Löwer M, Taube C, Becker M, Hain T, Dietzen S, Stassen M, Huber M, Lohoff M, Campos Chagas A, Andersen J, Kotál J, Langhansová H, Kopecký J, Schild H, Kotsyfakis M, Schmitt E, Bopp T. 2015: Tick Salivary Sialostatin L Represses the Initiation of Immune Responses by Targeting IRF4-Dependent Transcription in Murine Mast Cells. J Immunol.  195: 621-631.

Caisová V, Vieru A, Kumžáková Z, Glaserová S, Husníková H, Vácová N, Krejčová G, Paďouková L, Jochmanová I, Wolf KI, Chmelař J, Kopecký J, Ženka J. 2016: Innate immunity based cancer immunotherapy: B16-F10 murine melanoma model. BMC Cancer 16: 940.

Waldmannová E, Caisová V, Fáberová J, Sváčková P, Kovářová M, Sváčková D, Kumžáková Z, Jačková A, Vácová N, Nedbalová P, Horká M, Kopecký J, Ženka J. 2016: The use of Zymosan A and bacteria anchored to tumor cells for effective cancer immunotherapy: B16-F10 murine melanoma model. Int. Immunopharmacol. 39: 295-306.

Chmelař J, Kotál J, Kopecký J, Pedra JHF, Kotsyfakis M. 2016: All For One and One For All on the Tick-Host Battlefield. Trends Parasitol. 32: 368-377.

Elsterova J, Palus M, Sirmarova J, Kopecky J, Niller HH, Ruzek D. 2017: Tick-borne encephalitis virus neutralization by high dose intravenous immunoglobulin. Ticks Tick Borne Dis. 2: 253-258.

Rezkova M, Kopecky J. 2017: Anti-tumour necrosis factor activity in saliva of various tick species and its appearance during the feeding period. Folia Parasitol (Praha). 64: 032

Caisová V, Uher O, Nedbalová P, Jochmanová I, Kvardová K, Masáková K, Krejčová G, Paďouková L, Chmelař J, Kopecký J, Ženka J 2018: Effective cancer immunotherapy based on combination of TLR agonists with stimulation of phagocytosis. Int. Immunopharmacol. 59:86-96.

Lieskovská J, Páleníková J, Langhansová H, Chmelař J, Kopecký J. 2018: Saliva of Ixodes ricinus enhances TBE virus replication in dendritic cells by modulation of pro-survival Akt pathway. Virology. 514: 98-105.

 

Supervised Bachelor Thesis:

 

Klára Koutská: Vaccine against Lyme disease (literature review)

Why does Lyme disease vaccine not yet exist? Borrelia of Borrelia burgdorferi sensu lato complex, human pathogenicity, clinic, antigenic composition. Why has Lymerix vaccine failed? Possibilities of “classic” vaccines versus “trans-block” vaccines.

Anna Kovaříková: Possibilities of using tick saliva proteins in human medicine (literature review)

  1. Overview of tick saliva molecules with antihemostatic or immunomodulatory effects
  2. Use of tick proteins for the treatment of human diseases - testing in animal models
  3. Assessment of applicability of the tick saliva proteins for the treatment of specific human diseases (allergy, autoimmune disorders of homeostasis).