Služby nabízené v rámci infrastruktury C4SYS
Our laboratory studies molecular and cellular factors involved in the mechanism of pathogen transmission by ticks, mainly Lyme borreliosis (LB) spirochetes and tick-borne encephalitis virus (TBEV). Their molecular ecology and modern diagnostic techniques have been elaborated. Other tick-borne pathogens antimicrobial peptides are also studied.
Services are offered in the frame of the C4SYS research infrastructure. If you are interested in our services, contact us through the C4SYS webpage:
Laboratory of Molecular Ecology of Vectors and Pathogens provides detection and identification of tick-borne pathogens, analyses of their interactions with ticks and hosts, transmission of tick-borne pathogens to mammalian hosts, and identification and analyses of antimicrobial peptides. Please contact us regarding the availability of different models.
Fluorescent and electron microscopy analyses are also provided – please contact us on availability, if you are interested.
Laboratory has access to BSL2 and BSL lab space, both including animal facility (mice).
Host and vector response to infection
Bacterial and viral infections affect the infected cells and organisms by many ways. The process of infection, effects on the infected cells on the level of mRNA and proteins can be studied, rate of infection etc. Antiviral cellular response can be assessed as well.
Molecular ecology and epidemiology
Temporal and spatial distribution of tick-borne and other pathogens can be performed by several approaches, including a possibility to identify the hosts of the ticks. Genetic variability of the pathogens can be performed as well. This information is important for prediction of a risk of pathogen transmission. Analyses can be performed on samples provided by the customer.
Services include identification of antimicrobial molecules in genomic/transcriptomic data, their production and analyses of their antimicrobial activity. Antimicrobial molecules comprise a wide group of peptide types from many different organisms. Please contact us regarding the molecules and organisms you are interested in.