Faculty of Science, University of South Bohemia
Branišovská 31, 37005 České Budějovice
Building D, first floor,
Door number D 01 016
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
ORCID ID: 0000-0002-6678-1618
prof. Hassan Hashimi, Ph.D.
Head of the Laboratory of Eukaryotic Cell Architecture (LECA)
Research & pedagogical history (Reverse Chronological Order):
Group leader | ||
Professor | Department of Molecular Biology and Genetics, Faculty of Sciences, University of South Bohemia, České Budějovice, Czech Republic | |
Member of Panel 303 ‘Cell, Developmental and Evolutionary Biology, Regeneration and Reproduction’ | Czech Science Foundation, Prague, Czech Republic | |
Principle Investigator of Working Group | at the Laboratory of Molecular Biology of Protists, Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic | |
Member and head of the Molecular and Cell Biology Module | Integrative biology Doctoral Study Program CommitteeFaculty of Sciences, University of South Bohemia, České Budějovice, Czech RepublicFaculty of Sciences, University of South Bohemia, České Budějovice, Czech Republic | |
Habilitated Associate Professor (i.e. docent) | Department of Molecular Biology and Genetics, Faculty of Sciences, University of South Bohemia, České Budějovice, Czech Republic | |
Research Scientist | Laboratory of Molecular Biology of Protists, Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic | |
Assistant professor | Department of Molecular Biology and Genetics, Faculty of Sciences, University of South Bohemia, České Budějovice, Czech Republic | |
Post Doctoral Researcher | Laboratory of Molecular Biology of Protists, Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic |
Education
Ph.D. in Molecular Biology and Biochemistry | Faculty of Science, University of South Bohemia, České Budějovice, Czech Republic | |
Mgr. in Cell and Developmental Biology | (Červený diplom) Faculty of Biology, University of South Bohemia, České Budějovice, Czech Republic | |
B.Sc. in Biochemistry and Molecular Biology | University of Massachusetts at Amherst, USA |
Conferences and Seminars
Invited talks (reverse chronological order):
XXVIII Biochemistry Congress of the Czech and Slovak Societies for Biochemistry & Molecular Biology, Prague, Czech Republic | ‘Euglenazoans Bend the Rules of How the MICOS Complex Shapes Mitochondria’ | |
Swiss Trypanosomatid Meeting 2025, Schloss Münchenwiler, Switzerland | ‘My trek with André: The search for Mic60 in Euglenozoa’ | |
International Rhodobacter Symposium 2025, Wagenigen, The Netherlands | ‘Introcytoplasmic-membrane development in alphaproteobacteria involves the homolog of the mitochondrial crista-developing protein Mic60’ | |
Gymnázium Jírovcova, České Budějovice, Czech Republic | ‘How a meme started: the origin of mitochondria’ (Popularization seminar) | |
Czech BioImaging Imaging Principles of Life, Hradec Králové, Czech Republic | ‘Volumetric electron microscopy demonstrates a giant virus-encoded protein remodels mitochondria’ (Conference presentation) | |
Imaging Centre, European Molecular Biology Laboratory, Heidelberg, Germany | ‘The evolutionary history of the ancient mitochondrial membrane sculptor Mitofilin: from alphaproteobacteria to trypanosomes’ (Seminar) | |
Institute of Human Genetics, Medical University of Innsbruck, Innsbruck, Austria | ‘The evolutionary history of the ancient mitochondrial membrane sculptor Mitofilin: from alphaproteobacteria to trypanosomes’ (Seminar) | |
Algatech, Institute of Microbiology, Czech Academy of Sciences, Třeboň, Czech Republic | ‘The structure and function of the crista-developing Mic60 protein are largely conserved in alphaproteobacteria’ (Seminar) | |
International Society of Endocytobiology Symposium, České Budějovice, Czech Republic | ‘The structure and function of the crista-developing Mic60 protein are largely conserved in alphaproteobacteria’ (Conference presentation) | |
Institute of Microbiology, Czech Academy of Sciences, Online | ‘Exploring the diversity of mitochondrial cristae’ (Seminar) | |
Board of Directors Meeting, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic | ‘The evolutionary cell biology of mitochondrial cristae’ (Mini-symposium) | |
International Society of Evolutionary Protsitology Series on Protist Genomics, Diversity and Evolution, Online | ‘What does a reassessment of crista diversity in eukaryotes say about human mitochondria?’ (Seminar) | |
Department of Parasitology, Charles University, Prague Czech Republic) | ‘The trypanosome MICOS complex: a step toward a holistic view of mitochondrial cristae diversity’ (Seminar) | |
Gymnázium Jírovcova, České Budějovice, Czech Republic | ‘Factors involved in building the cristae of mitochondria’ (Popularization seminar) | |
University of South Bohemia, Faculty of Science, České Budějovice, Czech Republic) | ‘How the history of trypanosome RNA editing research shows the process of getting the mechanism behind a biological process after its initial observation’ PEDAGOGICAL HABILITATION LECTURE (oral presentation) | |
39th Annual Advances in Molecular Biology and Genetics, Prague Czech Republic | ‘It’s not just about U: RNA editing in trypanosomes’ (Seminar) | |
Department of Parasitology, Charles University , Prague Czech Republic | ‘It’s not just about U: RNA editing in trypanosomes’ (Seminar) | |
Marie Curie ITN RNPnet 2nd Summer School, Montpellier France | ‘The Biochemical Characterization of RNA Editing’ (Seminar) | |
37th Annual Advances in Molecular Biology and Genetics, Prague Czech Republic | ‘RNA editing: from obscurity to ubiquity’ (Seminar) | |
16th American Society for Tropical Medicine and Hygiene Meeting, Altanta, USA | ‘A mitochondrial cation/proton antiporter is essential in both life stages of Trypanosoma brucei brucei and the akinetoplastic Trypanonsoma brucei evansi’ (Conference presentation) | |
34th Annual Advances in Molecular Biology and Genetics , Prague Czech Republic | ‘RNA editing: from obscurity to ubiquity’ (Seminar) | |
33rd Annual Advances in Molecular Biology and Genetics , Prague Czech Republic | ‘Will this bug be a beast? Justifying Trypanosoma brucei as a model system’ (Seminar) | |
The Mitochondrion of Trypanosoma brucei enters the post-proteomic era symposium , Třešt´, Czech Republic) | ‘The putative mitochondrial RNA binding complex 1 of Trypanosoma brucei’ (Conference Presentation) | |
COST B-22 Expert Meeting, Cell Organelles of Protazoan Parasites: From Basic Science to Drug Targets, Prague Czech Republic | ‘RNA editing accessory factors in Trypanosoma brucei’ (Conference Presentation) |
Conference Presentations (notable poster presentation included; reverse chronological order):
Protistology Open, Prague, Czech Republic | ‘MICOS coordinates election transport chain biogenesis and membrane elaboration during crista maturation’ | |
British Society for Parasitology Trypanosomiasis and Leishmaniasis Seminar 2025, České Budějovice, Czech Republic | ‘Filling in the missing pieces of the trypanosomal cytochrome c reductase complex: Overlooked microprotein subunits are revealed by complexome profiling’ | |
International Congress of Protistology 2025, Seoul, South Korea | ‘Euglenazoans bend the rules of how the MICOS complex shapes mitochondria’ | |
Czech-Slovak Bioenergetic Conference, Telč, Czech Republic | ‘Cryptic mitofilin proteins bend the rules of how MICOS acts on mitochondria in trypanosomes’ (Oral presentation) | |
25th Cytoskeletal Club, Vranovská Ves, Czech Republic | ‘TbPH1: a kinetoplastid-specific pleckstrin homology domain containing kinesin-like protein’ (Oral Presentation) | |
British Society for Parasitology Spring Meeting, Cambridge, UK | ‘The dynamics of mitochondrial RNA binding complex in Trypanosoma brucei and its petite mutant under optimized immobilization conditions’ (Oral presentation) | |
Molecular Parasitology Meeting, Woods Hole, USA | ‘A mitochondrial cation/proton antiporter is essential in both life stages of Trypanosoma brucei brucei and the akinetoplastic Trypanonsoma brucei evansi’ (Oral presentation) - Awarded best talk | |
British Society for Parasitology Spring Meeting, , Glasgow, UK | ‘Functional characterization of a putative mitochondrial cation/proton antiporter in both life stages of Trypanosoma brucei brucei and the akinetoplastic Trypanonsoma brucei evansi’ (Oral presentation) | |
RNA club, Brno Czech Republic | ‘The putative mitochondrial RNA binding complex 1 of Trypanosoma brucei’ (Oral presentation) | |
34th Jírovec’s Protistological Days, Peklo, Czech Republic | ‘Is TbRGG1 really involved in RNA editing in the mitochondrion of Trypansoma brucei?’ (Oral presentation) | |
RNA club, Prague, Czech Republic | ‘Functional analysis of guide RNA-binding proteins involved in mitochondrial RNA editing in Trypanosoma brucei (Oral presentation) |
Awards
Important paper from the Biology Centre, CAS |
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Excellent grant evaluation (i.e. Top 20% grants) | Czech Science Foundation (CSF) | |
Czech-BioImaging Open Access Project | ‘Observation of mitochondrial cristae in three dimensions by semi-automated segmentation of highly contrasted membranes’ (78.5 K CZK) | |
Top cited article in the Journal of Eukaryotic Microbiology for 2011-2012 |
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Best result for 2018 | Scientific Board of the Biology Centre, Czech Academy of Sciences | |
Burroughs Wellcome Fund-ASTMH Talk Award | Molecular Parasitology Meeting XXIII, Woods Hole, USA | |
Best poster presentation | 8th International Conference on Mitochondrial Physiology and Pathology, September 2011, Bordeaux France | |
RNA Society Travel Fellowship | to attend RNA Society Meeting June 2010 in Seattle, USA |
Publications
- Hashimi H. (2025) Cell biology: A new dynamin superfamily protein remodels mitochondrial dynamics Current Biology 35: R218-R221.
DOI: 10.1016/j.cub.2025.01.069 - Hashimi H., Gahura O., Pánek T. (2025) Bringing together but staying apart: decisive differences in animal and fungal mitochondrial inner membrane fusion Biological Reviews 100: 920-935.
DOI: 10.1111/brv.13168 - Sheikh S., Turpin Knotková B., Benz C., Eliáš M., Bílý T., Bondar A., Tesařová M., Stříbrná E., Heller J., Meinecke M., Hashimi H. (2025) The core MICOS complex subunit Mic60 has been substituted by two cryptic mitofilin-containing proteins in Euglenozoa. Molecular Biology and Evolution 42: msaf289.
DOI: 10.1093/molbev/msaf289 - Lukeš J., Speijer D., Panicucci Zíková A., Alfonzo J., Hashimi H., Field M. (2023) Trypanosomes as a magnifying glass for cell and molecular biology Trends in Parasitology 39: 902–912.
DOI: 10.1016/j.pt.2023.08.004 - Muñoz-Gómez S.A., Cadena L., Gardiner A.T., Leger M.M., Sheikh S., Connell L.B., Bílý T., Kopejtka K., Beatty T., Koblížek M., Roger A., Slamovits C.H., Lukeš J., Hashimi H. (2023) Intracytoplasmic-membrane development in alphaproteobacteria involves the homolog of the mitochondrial crista-developing protein Mic60 Current Biology 33: 1099 - 1111. DOI: 10.1016/j.cub.2023.02.059
- Sheikh S., Pánek T., Gahura O., Týč J., Záhonová K., Lukeš J., Eliáš M., Hashimi H. (2023) A novel group of dynamin-related proteins shared by eukaryotes and giant viruses is able to remodel mitochondria from within the matrix Molecular Biology and Evolution 40: msad134. DOI: 10.1093/molbev/msad134
- Benz C., Muller N., Kaltenbrunner S., Váchová H. , Vancová M., Lukeš J., Varga V., Hashimi H. (2022) Kinetoplastid-specific X2-family kinesins interact with a kinesin-like pleckstrin homology domain protein that localizes to the trypanosomal microtubule quartet Molecular Microbiology 118: 155–174. DOI: 10.1111/mmi.14958
- Kaurov I., Heller J., Deisenhammer S., Potěšil D., Zdráhal Z., Hashimi H. (2022) The essential cysteines in the CIPC motif of the thioredoxin-like Trypanosoma brucei MICOS subunit TbMic20 do not form an intramolecular disulfide bridge in vivo Molecular and Biochemical Parasitology 248: 111463. DOI: 10.1016/j.molbiopara.2022.111463
- Bílý T., Sheikh S., Mallet A., Bastin P., Pérez-Morga D., Lukeš J., Hashimi H. (2021) Ultrastructural Changes of the Mitochondrion During the Life Cycle of Trypanosoma brucei. Journal of Eukaryotic Microbiology 68: e12846. DOI: 10.1111/jeu.12846
- Cadena L., Gahura O., Panicucci B., Panicucci Zíková A., Hashimi H. (2021) Mitochondrial Contact Site and Cristae Organization System and F1FO-ATP Synthase Crosstalk Is a Fundamental Property of Mitochondrial Cristae mSphere 16: e0032721. DOI: 10.1128/mSphere.00327-21
- Durante I., Butenko A., Rašková V., Charyyeva A., Svobodová M., Yurchenko V., Hashimi H., Lukeš J. (2020) Large-Scale Phylogenetic Analysis of Trypanosomatid Adenylate Cyclases Reveals Associations with Extracellular Lifestyle and Host-Pathogen Interplay Genome Biology and Evolution 12: 2403–2416. DOI: 10.1093/gbe/evaa226
- Pánek T., Eliáš M., Vancová M., Lukeš J., Hashimi H. (2020) Returning to the Fold for Lessons in Mitochondrial Crista Diversity and Evolution Current Biology 30: R575–R588. DOI: 10.1016/j.cub.2020.02.053
- Eichenberger C., Oeljeklaus S., Bruggisser J., Mani J. , Haenni B. , Kaurov I., Niemann M. , Zuber B. , Lukeš J., Hashimi H., Warscheid B., Schimanski B., Schneider A. (2019) The highly diverged trypanosomal MICOS complex is organized in a nonessential integral membrane and an essential peripheral module Molecular Microbiology 12: 1731–1743. DOI: 10.1111/mmi.14389
- Hashimi H. (2019) A parasite’s take on the evolutionary cell biology of MICOS PLOS Pathogens 15: e1008166. DOI: 10.1371/journal.ppat.1008166
- Maslov D., Opperdoes F.R., Kostygov A., Hashimi H., Lukeš J., Yurchenko V. (2019) Recent advances in trypanosomatid research: genome organization, expression, metabolism, taxonomy and evolution. Parasitology 146: 1–27. DOI: 10.1017/S0031182018000951
- Faktorová D., Bär A., Hashimi H., McKenney K., Horák A., Schnaufer A., Rubio M., Alfonzo J., Lukeš J. (2018) TbUTP10, a protein involved in early stages of pre-18S rRNA processing in Trypanosoma brucei Molecular and Biochemical Parasitology 225: 84–93. DOI: 10.1016/j.molbiopara.2018.09.003
- Kaurov I., Vancová M., Schimanski B., Cadena L.R., Heller J., Bílý T., Potěšil D., Eichenberger C., Bruce H., Oeljeklaus S., Warscheid B., Zdráhal Z., Schneider A., Lukeš J., Hashimi H. (2018) The diverged trypanosome MICOS complex as a hub for mitochondrial cristae shaping and protein import Current Biology 28: 3393–3407. DOI: 10.1016/j.cub.2018.09.008
- Lukeš J., Butenko A., Hashimi H., Maslov D., Votýpka_LBMP J., Yurchenko V. (2018) Trypanosomatids Are Much More than Just Trypanosomes: Clues from the Expanded Family Tree Trends in Parasitology 34: 466-480.. DOI: 10.1016/j.pt.2018.03.002
- Benz C., Stříbrná E., Hashimi H., Lukeš J. (2017) Dynamin-like proteins in Trypanosoma brucei: A division of labour between two paralogs? PLoS ONE 12: e0177200. DOI: 10.1371/journal.pone.0177200
- Dixit S., Müller-McNicoll M., David V., Zarnack K., Ule J., Hashimi H., Lukeš J. (2017) Differential Binding of Mitochondrial Transcripts by MRB8170 and MRB4160 Regulates Distinct Editing Fates of Mitochondrial mRNA in Trypanosomes mBio 8: e02288-16. DOI: 10.1128/mBio.02288-1
- Hashimi H., Kaltenbrunner S., Zíková A., Lukeš J. (2016) Trypanosome Mitochondrial Translation and Tetracycline: No Sweat about Tet PLoS Pathogens 12: e1005492. DOI: 10.1371/journal.ppat.1005492
- Read L., Lukeš J., Hashimi H. (2016) Trypanosome RNA editing: the complexity of getting U in and taking U out. Wiley Interdiscip Reviews RNA 7: 33-51. DOI: 10.1002/wrna.1313
- David V., Flegontov P., Gerasimov E.S., Tanifuji G., Hashimi H., Logacheva M., Maruyama S., Onodera N., Gray M., Archibald J., Lukeš J. (2015) Gene loss and error-prone RNA editing in the mitochondrion of Perkinsela, an endosymbiotic kinetoplastid mBio 6: e01498-15. DOI: 10.1128/mBio.01498-15
- Huang Z., Faktorová D., Křížová A., Kafková L., Read L., Lukeš J., Hashimi H. (2015) Integrity of the core mitochondrial RNA-binding complex 1 is vital for trypanosome RNA editing RNA 21: 2088-2102. DOI: 10.1261/rna.052340.115
- Verner Z., Basu S., Benz C., Dixit S., Dobáková E., Faktorová D., Hashimi H., Horáková E., Huang Z., Paris Z., Pena P., Ridlon L., Týč J., Wildridge D., Zíková A., Lukeš J. (2015) The malleable mitochondrion of Trypanosoma brucei Internation Review of Cell and Molecular Biology 315: 73-151. DOI: 10.1016/bs.ircmb.2014.11.001
- Huang Z., Kaltenbrunner S., Šimková E., Staněk D., Lukeš J., Hashimi H. (2014) The dynamics of mitochondrial RNA-binding protein complex in Trypanosoma brucei and its petite mutant under optimized immobilization conditions Eukaryotic Cell 13: 1232-1240. DOI: 10.1128/EC.00149-14
- Ammerman M., Tomasello D., Faktorová D., Kafková L., Hashimi H., Lukeš J., Read L. (2013) A Core MRB1 Complex Component Is Indispensable for RNA Editing in Insect and Human Infective Stages of Trypanosoma brucei PLoS ONE 8: e78015. DOI: 10.1371/journal.pone.0078015
- Cristodero M., Mani J., Oeljeklaus S., Aeberhard L., Hashimi H., Ramrath D., Lukeš J., Warscheid B., Schneider A. (2013) Mitochondrial translation factors of Trypanosoma brucei: Elongation factor-Tu has a unique subdomain that is essential for its function Molecular microbiology 90: 744-755. DOI: 10.1111/mmi.12397
- Hashimi H., Mcdonald L., Lukeš J., Stříbrná E. (2013) Trypanosome Letm1 Protein Is Essential for Mitochondrial Potassium Homeostasis Journal of Biological Chemistry 288: 26914-26925.
- Hashimi H., Zimmer S., Ammerman M., Read L., Lukeš J. (2013) Dual core processing: MRB1 is an emerging kinetoplast RNA editing complex Trends in Parasitology 29: 91-99. DOI: 10.1016/j.pt.2012.11.005
- Ammerman M., Downey K., Hashimi H., Fisk J., Tomasello D., Kafkova L., Faktorová D., King T., Lukeš J., Read L. (2012) Architecture of the trypanosome RNA editing accessory complex MRB1. Nucleic Acids Research 40: 5637-5650. DOI: 10.1093/nar/gks211
- Kafková L., Ammerman M., Faktorová D., Fisk J., Zimmer S., Sobotka R., Read L., Lukeš J., Hashimi H. (2012) Functional characterization of two paralogs that are novel RNA binding proteins influencing mitochondrial transcripts of Trypanosoma brucei RNA 18: 1-16.
- Ammerman M., Hashimi H., Novotná L., Číčová Z., Mcevoy S., Lukeš J., Read L. (2011) MRB3010 is a core component of the MRB1 complex that facilitates an early step of the kinetoplastid RNA editing process. RNA 17: 865–877. DOI: 10.1261/rna.2446311
- Paris Z., Hashimi H., Lun S., Alfonzo J., Lukeš J. (2011) Futile import of tRNAs and proteins into the mitochondrion of Trypanosoma brucei evansi. Molecular and Biochemical Parasitology 176: 116–120. DOI: 10.1016/j.molbiopara.2010.12.010
- Hashimi H., Benkovičová V., Čermáková P., Lai D., Horváth A., Lukeš J. (2010) The assembly of F1FO-ATP synthase is disrupted upon interference of RNA editing in Trypanosoma brucei. International Journal for Parasitology 40: 45–54. DOI: 10.1016/j.ijpara.2009.07.005
- Lukeš J., Hashimi H., Verner Z., Číčová Z. (2010) The remarkable mitochondrion of trypanosomes and related flagellates. In: W. de Souza (Ed.), Structures and Organelles in Pathogenic Protists. Microbiology Monographs 17. Springer-Verlag, Berlin 228–252.
- Hashimi H., Číčová Z., Novotná L., Wen Y., Lukeš J. (2009) Kinetoplastid guide RNA biogenesis is dependent on subunits of the mitochondrial RNA binding complex 1 and mitochondrial RNA polymerase. RNA 15: 588-599. DOI: 10.1261/rna.1411809
- Hashimi H., Zíková A., Panigrahi A., Stuart K., Lukeš J. (2008) TbRGG1, an essential protein involved in kinetoplastid RNA metabolism that is associated with a novel multiprotein complex. RNA 14: 970-980. DOI: 10.1261/rna.888808
- Lai D., Hashimi H., Lun Z., Ayala F., Lukeš J. (2008) Adaptations of Trypanosoma brucei to gradual loss of kinetoplast DNA: Trypanosoma equiperdum and Trypanosoma evansi are petite mutants of T. brucei. PNAS 105: 1999-2004. DOI: 10.1073/pnas.0711799105
- Lukeš J., Hashimi H., Zíková A. (2005) Unexplained complexity of the mitochondrial genome and transcriptome in kinetoplastid flagellates. Current Genetics 48: 277-299. DOI: 10.1007/s00294-005-0027-0
Publication metrics
Collated from Web of Science on 31 March 2026:
Total publications: 44
Hirsh index: 21
Total citating articles (excluding self-citations): 1071
Total citations (excluding self-citations): 1617
Collated from Google Scholar on 31 March 2026:
Hirsh index: 24
i10-index (# articles with ≥10 citations): 34
Total citations: 2698
